The environmental triggers of autoimmunity has always been suspected but extremely difficult to prove. Apart from smoking, there is very little else that has been proven to be complicit in the causation of rheumatoid arthritis. So it makes this article relevant in nailing down the potential cause that everyone has suspected all along.
OBJECTIVES: To compare the presentation of seropositive and seronegative early rheumatoid arthritis (RA) in disease-modifying antirheumatic drug (DMARD)-naïve patients classified according to the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria.
Hydroxychloroquine blood levels in routine clinical care grant us the opportunity to identify non-adherence and impact upon it to improve SLE disease activity and potentially avoid more toxic immunosuppressive regimens.
Insufficient data exist presently regarding whether these blood levels will be instructive in identifying individuals at higher risk of retinal toxicity. Our results support the prescription of hydroxychloroquine based on actual (capped at 400 mg per day) rather than ideal body weight and did not demonstrate differences in blood levels in those who were obese or short stature.
At this moment, doing additional ultrasound examinations to look at the joints to “redefine” remission may be an overkill. This study shows that it does not offer better outcomes. Apart from increasing cost and being time consuming, musculoskeletal ultrasounds are very operater dependant.
A gentleman with a history of gout presented with right foot pain. It has been a nagging pain over the past 7 months.
With biologics remaining astronomically pricey, helping patients manage both their disease and cost becomes a dilemma for many rheumatologists. The conundrum of helping physical pain but leaving patients in financial ruins plague the management of rheumatoid arthritis. Maximising the existing…