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Arthrogryposis

The musculo-pathology conference yielded a very interesting case as presented by the Paediatric team. A small for gestation baby was delivered and of immediate note was the joint contractures and the evidence of shallow breathing, that could not support life. The baby was put on ventilator support. An attempt at muscle biopsies revealed fibrous strands in place of the muscle at both the upper and lower limb regions. Prognosis was extremely poor and withdrawal of therapy was finally agreed upon with the family.

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21

Tofacitinib vs Methotrexate in Rheumatoid arthritis

Methotrexate is the most frequently used first-line antirheumatic drug. We report the findings of a phase 3 study of monotherapy with tofacitinib, an oral Janus kinase inhibitor, as compared with methotrexate monotherapy in patients with rheumatoid arthritis who had not previously received methotrexate or therapeutic doses of methotrexate.

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11

EULAR 2014

We’re following the #eular2014 hashtag. For updates follow us on 1. Facebook. Link here. 2. Twitter. Link here.

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More links between infection and RA
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More links between infection and RA

The article below suggests the possible causative mechanism of RA. A step closer to a preventive strategy? Arthritis Res Ther. 2013;15(5):R111. Bacterial lipopolysaccharides form procollagen-endotoxin complexes that trigger cartilage inflammation and degeneration: implications for the development

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9

Narcolepsy is an autoimmune disease!

A new study that offers some of the most compelling evidence to date for the idea of "mimicry," where the immune system attacks a body protein because of its similarity to a pathogen protein, confirms that narcolepsy is an autoimmune disease.

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